As of Monday, the country’s caseload was 40,016,654 with a death toll of 649,426, according to a tally by the Johns Hopkins University (JHU).
To date, 13 U.S. states have each confirmed at least 1 million COVID-19 cases, showed the tally.
California topped the state-level caseload list, with over 4.4 million cases, followed by Texas with more than 3.7 million and Florida with over 3.3 million.
The United States remains the nation worst hit by the pandemic, with the world’s most cases and deaths, making up more than 18 percent of the global caseload and nearly 14 percent of the global deaths.
The staggering 40 million milestone came as weary Americans spent their second Labor Day, 19 months into the pandemic.
The U.S. COVID-19 caseload reached 10 million on Nov. 9, 2020, crossed 20 million on Jan. 1, 2021, and exceeded 30 million on March 24.
Daily COVID-19 infections are more than four times what the United States was seeing on Labor Day last year, or a 316 percent increase, USA Today reported on Monday, citing data from the Johns Hopkins University.
Hospitalizations are also up by 158 percent compared to Labor Day weekend a year ago, according to data from the Department of Health and Human Services.
The current seven-day moving average was 153,246, which was 123.6 percent higher than the figure observed approximately one year ago and 1,217.0 percent higher than the lowest record on June 18, 2021, according to the latest weekly report by the U.S. Centers for Disease Control and Prevention (CDC).